Project Information

PI nameProf. Kibor Alfred
Project title“Isolation of Secondary Metabolites from Teclea nobilis and Rapanea melanophloes active against Schistosoma mansoniIsolation of Secondary Metabolites from Teclea nobilis and Rapanea
PartnersXXX
Collaborators
  • 1. Prof. Josphat Matasyoh,
  • Martin Njogu Kimani MSC student Chemistry
Grant amountKES. 400,000
Project StatusEnded
Project LocationEgerton University Chemistry Department
Project description Helminths belong to two major groups: platyhelminthes and nemathelminthes (Ijagboneand Olagunju, 2006). Nemathelminthes include roundworms, hook worms and whip worms which cause high morbidity and mortality in humans and animals. These parasites are common in sub-Saharan Africa due to multiple factors which include poor hygienic conditions, poverty, malnutrition, ignorance, lack of clean water as well as limited access to preventive measures and health care(Zvi et al., 2010). Gastrointestinal parasites have also been reported to be a major menace facing animals and birds. These parasites are known todiminish the animals’ survival, growth rate and reproductive performance thus affecting their overall production. A study conducted in Kenya, showed that Helminthiosis accounted for the second most important disease accounting for 21% of the deaths from parasitic conditions, between 1989 and 1998 in chicken (Permin et al., 1999).It has been estimated that more than 750 million chickens, guinea fowls and ducklings in Africa die each year as a result of various infections, helminthosis being a major contributor (Maturet al., 2010). Therefore, the economic and social impact of helminth cannot be underestimated with the effect in human and livestock ranging from stunted growth, reduced weight gain, diarrhoea,anaemia, respiratory problems, reduced productivity and death especially in the tropics and developing countries(Jozef et al., 2011;Velkers et al.,2011). The use of synthetic drugs has been effective in treatment and control of helminth infections However, development of anti-helmintic resistance, the presence ofdrug residues, deficient livestock extension services and the high cost of conventional anti-helmintics, has led to the evaluation of medicinal plants as an alternative source of anti-helmintics for treatment of human and livestock diseases.
Project Start12/11/2012
Project End30/01/2013
Expected outputs1. Use of natural products from Rapanea melanophloeos and Teclea nobilis for the treatment of Schistosoma mansoni infection in humans Results from this study shows that both the four furoquinoline alkaloids and the essential oil from T. nobilis leaves as well as the two Myrsinoic acid compounds from R. melanophleoes have potential applicability in the control of S. mansoni miracidia. This study underscores the fact that bioactive plant constituents can be useful agents in the control of Schistosomiasis. These findings also show that these compounds can be used as lead compounds in the development of new, biodegradable, environmentally benign and more potent anti-helmintics. 2. New knowledge on the use of chemical compounds from medicinal plants for the treatment of parasitic diseases 3. New knowledge on the structural composition of volatile and non-volatile compounds from Rapanea melanophloeos and Teclea nobilis